Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis

Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis

Rheumatoid arthritis (RA)-associated IgG antibodies such as anti-citrullinated protein antibodies (ACPAs) have diverse glycosylation variants; however, key sugar chains modulating the arthritogenic activity of IgG remain to be clarified. Here, we show that reduced sialylation is a common feature of...

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Bibliographic Details
Main Authors: Ohmi, Yuhsuke, Ise, Wataru, Harazono, Akira, Takakura, Daisuke, Fukuyama, Hidehiro, Baba, Yoshihiro, Narazaki, Masashi, Shoda, Hirofumi, Takahashi, Nobunori, Ohkawa, Yuki, Ji, Shuting, Sugiyama, Fumihiro, Fujio, Keishi, Kumanogoh, Atsushi, Yamamoto, Kazuhiko, Kawasaki, Nana, Kurosaki, Tomohiro, Takahashi, Yoshimasa, Furukawa, Koichi
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822049/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822049/

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