Activation of IGF1R/p110β/AKT/mTOR confers resistance to α-specific PI3K inhibition

Activation of IGF1R/p110β/AKT/mTOR confers resistance to α-specific PI3K inhibition

Bibliographic Details
Main Authors:	Leroy, Cedric, Ramos, Pedro, Cornille, Karen, Bonenfant, Debora, Fritsch, Christine, Voshol, Hans, Bentires-Alj, Mohamed
Format:	Online
Language:	English
Published:	BioMed Central 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820873/

Similar Items

Presence of both alterations in FGFR/FGF and PI3K/AKT/mTOR confer improved outcomes for patients with metastatic breast cancer treated with PI3K/AKT/mTOR inhibitors
by: Wheler, Jennifer J., et al.
Published: (2016)

PI3K/AKT/mTOR Pathway in Angiogenesis
by: Karar, Jayashree, et al.
Published: (2011)

Targeting the PI3K/Akt/mTOR Pathway – Beyond Rapalogs
by: Markman, Ben, et al.
Published: (2010)

Role of dual PI3/Akt and mTOR inhibition in Waldenstrom's Macroglobulinemia
by: Sacco, Antonio, et al.
Published: (2010)

Targeting the PI3K-AKT-mTOR signaling network in cancer
by: Khan, Khurum H., et al.
Published: (2013)

AKTivation of PI3K/AKT/mTOR signaling pathway by KSHV
by: Bhatt, Aadra P., et al.
Published: (2013)

Targeting PI3K/Akt/mTOR Signaling in Cancer
by: Porta, Camillo, et al.
Published: (2014)

PI3K/Akt/mTOR inhibitors in breast cancer
by: Lee, Joycelyn JX, et al.
Published: (2015)

Outlook on PI3K/AKT/mTOR inhibition in acute leukemia
by: Fransecky, Lars, et al.
Published: (2015)

The Role of PI3K/Akt/mTOR Signaling in Gastric Carcinoma
by: Matsuoka, Tasuku, et al.
Published: (2014)

The Paradox of Akt-mTOR Interactions
by: Vadlakonda, Lakshmipathi, et al.
Published: (2013)

Akt and mTOR in B Cell Activation and Differentiation
by: Limon, Jose J., et al.
Published: (2012)

Akt and mTOR mediate programmed necrosis in neurons
by: Liu, Q, et al.
Published: (2014)

IGF-II transcription in skeletal myogenesis is controlled by mTOR and nutrients
by: Erbay, Ebru, et al.
Published: (2003)

All PI3Kinase signaling is not mTOR: dissecting mTOR-dependent and independent signaling pathways in T cells
by: Gamper, Christopher J., et al.
Published: (2012)

Genomewide Analysis of Inherited Variation Associated with Phosphorylation of PI3K/AKT/mTOR Signaling Proteins
by: Hutz, Janna E., et al.
Published: (2011)

Potential Therapeutic Roles for Inhibition of the PI3K/Akt/mTOR Pathway in the Pathophysiology of Diabetic Retinopathy
by: Jacot, Jorge L., et al.
Published: (2011)

Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells
by: Kang, Sokbom, et al.
Published: (2012)

PI3K/Akt/mTOR, a Pathway Less Recognized for Staphylococcal Superantigen-Induced Toxicity
by: Krakauer, Teresa
Published: (2012)

Therapeutic targets for cancer: Current concepts with PI 3-K, Akt, & mTOR
by: Maiese, Kenneth
Published: (2013)

The PI3K/AKT/mTOR Signaling Pathway Is Overactivated in Primary Aldosteronism
by: Su, Hengchuan, et al.
Published: (2013)

Differential Effects of Selective Inhibitors Targeting the PI3K/AKT/mTOR Pathway in Acute Lymphoblastic Leukemia
by: Badura, Susanne, et al.
Published: (2013)

SMAD-PI3K-Akt-mTOR Pathway Mediates BMP-7 Polarization of Monocytes into M2 Macrophages
by: Rocher, Crystal, et al.
Published: (2013)

Activation of the Renal PI3K/Akt/mTOR Signaling Pathway in a DOCA-Salt Model of Hypertension
by: Ma, Seong Kwon, et al.
Published: (2012)

Roles of PI3K/AKT/GSK3/mTOR Pathway in Cell Signaling of Mental Illnesses
by: Kitagishi, Yasuko, et al.
Published: (2012)

Oxidant Stress and Signal Transduction in the Nervous System with the PI 3-K, Akt, and mTOR Cascade
by: Maiese, Kenneth, et al.
Published: (2012)

Molecular Alterations of PI3K/Akt/mTOR Pathway: A Therapeutic Target in Endometrial Cancer
by: Pavlidou, Athanasia, et al.
Published: (2014)

Activation of the PI3K/mTOR/AKT Pathway and Survival in Solid Tumors: Systematic Review and Meta-Analysis
by: Ocana, Alberto, et al.
Published: (2014)

Advanced glycation endproducts trigger autophagy in cadiomyocyte Via RAGE/PI3K/AKT/mTOR pathway
by: Hou, Xuwei, et al.
Published: (2014)

PI3K-AKT-mTOR-Signaling and beyond: the Complex Network in Gastroenteropancreatic Neuroendocrine Neoplasms
by: Briest, Franziska, et al.
Published: (2014)

Identification of a Role for the PI3K/AKT/mTOR Signaling Pathway in Innate Immune Cells
by: Xie, Songbo, et al.
Published: (2014)

PI3K-AKT-mTOR signaling in prostate cancer progression and androgen deprivation therapy resistance
by: Edlind, Merritt P, et al.
Published: (2014)

Vertical blockade of the IGFR- PI3K/Akt/mTOR pathway for the treatment of hepatocellular carcinoma: the role of survivin
by: Ou, Da-Liang, et al.
Published: (2014)

Sequential Dosing in Chemosensitization: Targeting the PI3K/Akt/mTOR Pathway in Neuroblastoma
by: Westhoff, Mike-Andrew, et al.
Published: (2013)

Increased Phosphorylation of PI3K/Akt/mTOR in the Obstructed Kidney of Rats with Unilateral Ureteral Obstruction
by: Ma, Seong Kwon, et al.
Published: (2013)

Selective Inhibition of PI3K/Akt/mTOR Signaling Pathway Regulates Autophagy of Macrophage and Vulnerability of Atherosclerotic Plaque
by: Zhai, Chungang, et al.
Published: (2014)

Inhibition of PI3K-AKT-mTOR pathway sensitizes endometrial cancer cell lines to PARP inhibitors
by: Charles-André Philip, et al.
Published: (2017-09-01)

Inhibition of PI3K/AKT/mTOR axis disrupts oxidative stress-mediated survival of melanoma cells
by: Hambright, Heather G., et al.
Published: (2015)

The PI3K-AKT-mTOR pathway activates recovery from general anesthesia
by: Zhang, Yun-Hui, et al.
Published: (2016)

PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma
by: Li, Xiaoman, et al.
Published: (2016)