Cell Cycle Regulatory Functions of the KSHV Oncoprotein LANA

Manipulation of cell cycle is a commonly employed strategy of viruses for achieving a favorable cellular environment during infection. Kaposi’s sarcoma-associated herpesvirus (KSHV), the primary etiological agent of several human malignancies including Kaposi’s sarcoma, and primary effusion lymphoma...

Full description

Bibliographic Details
Main Authors:	Wei, Fang, Gan, Jin, Wang, Chong, Zhu, Caixia, Cai, Qiliang
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811921/

id	pubmed-4811921
recordtype	oai_dc
spelling	pubmed-48119212016-04-08 Cell Cycle Regulatory Functions of the KSHV Oncoprotein LANA Wei, Fang Gan, Jin Wang, Chong Zhu, Caixia Cai, Qiliang Microbiology Manipulation of cell cycle is a commonly employed strategy of viruses for achieving a favorable cellular environment during infection. Kaposi’s sarcoma-associated herpesvirus (KSHV), the primary etiological agent of several human malignancies including Kaposi’s sarcoma, and primary effusion lymphoma, encodes several oncoproteins that deregulate normal physiology of cell cycle machinery to persist with endothelial cells and B cells and subsequently establish a latent infection. During latency, only a small subset of viral proteins is expressed. Latency-associated nuclear antigen (LANA) is one of the latent antigens shown to be essential for transformation of endothelial cells in vitro. It has been well demonstrated that LANA is critical for the maintenance of latency, episome DNA replication, segregation and gene transcription. In this review, we summarize recent studies and address how LANA functions as an oncoprotein to steer host cell cycle-related events including proliferation and apoptosis by interacting with various cellular and viral factors, and highlight the potential therapeutic strategy of disrupting LANA-dependent signaling as targets in KSHV-associated cancers. Frontiers Media S.A. 2016-03-30 /pmc/articles/PMC4811921/ /pubmed/27065950 http://dx.doi.org/10.3389/fmicb.2016.00334 Text en Copyright © 2016 Wei, Gan, Wang, Zhu and Cai. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Wei, Fang Gan, Jin Wang, Chong Zhu, Caixia Cai, Qiliang
spellingShingle	Wei, Fang Gan, Jin Wang, Chong Zhu, Caixia Cai, Qiliang Cell Cycle Regulatory Functions of the KSHV Oncoprotein LANA
author_facet	Wei, Fang Gan, Jin Wang, Chong Zhu, Caixia Cai, Qiliang
author_sort	Wei, Fang
title	Cell Cycle Regulatory Functions of the KSHV Oncoprotein LANA
title_short	Cell Cycle Regulatory Functions of the KSHV Oncoprotein LANA
title_full	Cell Cycle Regulatory Functions of the KSHV Oncoprotein LANA
title_fullStr	Cell Cycle Regulatory Functions of the KSHV Oncoprotein LANA
title_full_unstemmed	Cell Cycle Regulatory Functions of the KSHV Oncoprotein LANA
title_sort	cell cycle regulatory functions of the kshv oncoprotein lana
description	Manipulation of cell cycle is a commonly employed strategy of viruses for achieving a favorable cellular environment during infection. Kaposi’s sarcoma-associated herpesvirus (KSHV), the primary etiological agent of several human malignancies including Kaposi’s sarcoma, and primary effusion lymphoma, encodes several oncoproteins that deregulate normal physiology of cell cycle machinery to persist with endothelial cells and B cells and subsequently establish a latent infection. During latency, only a small subset of viral proteins is expressed. Latency-associated nuclear antigen (LANA) is one of the latent antigens shown to be essential for transformation of endothelial cells in vitro. It has been well demonstrated that LANA is critical for the maintenance of latency, episome DNA replication, segregation and gene transcription. In this review, we summarize recent studies and address how LANA functions as an oncoprotein to steer host cell cycle-related events including proliferation and apoptosis by interacting with various cellular and viral factors, and highlight the potential therapeutic strategy of disrupting LANA-dependent signaling as targets in KSHV-associated cancers.
publisher	Frontiers Media S.A.
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811921/
_version_	1613559188615593984

Cell Cycle Regulatory Functions of the KSHV Oncoprotein LANA

Similar Items