IRF-4-Mediated CIITA Transcription Is Blocked by KSHV Encoded LANA to Inhibit MHC II Presentation

IRF-4-Mediated CIITA Transcription Is Blocked by KSHV Encoded LANA to Inhibit MHC II Presentation

Peptides presentation to T cells by MHC class II molecules is of importance in initiation of immune response to a pathogen. The level of MHC II expression directly influences T lymphocyte activation and is often targeted by various viruses. Kaposi's sarcoma-associated herpesvirus (KSHV) encoded...

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Bibliographic Details
Main Authors: Cai, Qiliang, Banerjee, Shuvomoy, Cervini, Amanda, Lu, Jie, Hislop, Andrew D., Dzeng, Richard, Robertson, Erle S.
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814934/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814934/

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