Clinical features of TBK1 carriers compared with C9orf72, GRN and non-mutation carriers in a Belgian cohort

Loss-of-function mutations in TBK1 have been identified in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Van Mossevelde et al. compare TBK1-mutation carriers with FTD, ALS or FTD-ALS to patients carrying GRN or C9orf72 mutations. Differences are seen in age of onset, extrapy...

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Main Authors:	Van Mossevelde, Sara, van der Zee, Julie, Gijselinck, Ilse, Engelborghs, Sebastiaan, Sieben, Anne, Van Langenhove, Tim, De Bleecker, Jan, Baets, Jonathan, Vandenbulcke, Mathieu, Van Laere, Koen, Ceyssens, Sarah, Van den Broeck, Marleen, Peeters, Karin, Mattheijssens, Maria, Cras, Patrick, Vandenberghe, Rik, De Jonghe, Peter, Martin, Jean-Jacques, De Deyn, Peter P., Cruts, Marc, Van Broeckhoven, Christine
Format:	Online
Language:	English
Published:	Oxford University Press 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805085/

id	pubmed-4805085
recordtype	oai_dc
spelling	pubmed-48050852016-03-24 Clinical features of TBK1 carriers compared with C9orf72, GRN and non-mutation carriers in a Belgian cohort Van Mossevelde, Sara van der Zee, Julie Gijselinck, Ilse Engelborghs, Sebastiaan Sieben, Anne Van Langenhove, Tim De Bleecker, Jan Baets, Jonathan Vandenbulcke, Mathieu Van Laere, Koen Ceyssens, Sarah Van den Broeck, Marleen Peeters, Karin Mattheijssens, Maria Cras, Patrick Vandenberghe, Rik De Jonghe, Peter Martin, Jean-Jacques De Deyn, Peter P. Cruts, Marc Van Broeckhoven, Christine Original Articles Loss-of-function mutations in TBK1 have been identified in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Van Mossevelde et al. compare TBK1-mutation carriers with FTD, ALS or FTD-ALS to patients carrying GRN or C9orf72 mutations. Differences are seen in age of onset, extrapyramidal symptoms, and in memory, language and behaviour. Oxford University Press 2016-02 2015-12-16 /pmc/articles/PMC4805085/ /pubmed/26674655 http://dx.doi.org/10.1093/brain/awv358 Text en © The Author (2015). Published by Oxford University Press on behalf of the Guarantors of Brain. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Van Mossevelde, Sara van der Zee, Julie Gijselinck, Ilse Engelborghs, Sebastiaan Sieben, Anne Van Langenhove, Tim De Bleecker, Jan Baets, Jonathan Vandenbulcke, Mathieu Van Laere, Koen Ceyssens, Sarah Van den Broeck, Marleen Peeters, Karin Mattheijssens, Maria Cras, Patrick Vandenberghe, Rik De Jonghe, Peter Martin, Jean-Jacques De Deyn, Peter P. Cruts, Marc Van Broeckhoven, Christine
spellingShingle	Van Mossevelde, Sara van der Zee, Julie Gijselinck, Ilse Engelborghs, Sebastiaan Sieben, Anne Van Langenhove, Tim De Bleecker, Jan Baets, Jonathan Vandenbulcke, Mathieu Van Laere, Koen Ceyssens, Sarah Van den Broeck, Marleen Peeters, Karin Mattheijssens, Maria Cras, Patrick Vandenberghe, Rik De Jonghe, Peter Martin, Jean-Jacques De Deyn, Peter P. Cruts, Marc Van Broeckhoven, Christine Clinical features of TBK1 carriers compared with C9orf72, GRN and non-mutation carriers in a Belgian cohort
author_facet	Van Mossevelde, Sara van der Zee, Julie Gijselinck, Ilse Engelborghs, Sebastiaan Sieben, Anne Van Langenhove, Tim De Bleecker, Jan Baets, Jonathan Vandenbulcke, Mathieu Van Laere, Koen Ceyssens, Sarah Van den Broeck, Marleen Peeters, Karin Mattheijssens, Maria Cras, Patrick Vandenberghe, Rik De Jonghe, Peter Martin, Jean-Jacques De Deyn, Peter P. Cruts, Marc Van Broeckhoven, Christine
author_sort	Van Mossevelde, Sara
title	Clinical features of TBK1 carriers compared with C9orf72, GRN and non-mutation carriers in a Belgian cohort
title_short	Clinical features of TBK1 carriers compared with C9orf72, GRN and non-mutation carriers in a Belgian cohort
title_full	Clinical features of TBK1 carriers compared with C9orf72, GRN and non-mutation carriers in a Belgian cohort
title_fullStr	Clinical features of TBK1 carriers compared with C9orf72, GRN and non-mutation carriers in a Belgian cohort
title_full_unstemmed	Clinical features of TBK1 carriers compared with C9orf72, GRN and non-mutation carriers in a Belgian cohort
title_sort	clinical features of tbk1 carriers compared with c9orf72, grn and non-mutation carriers in a belgian cohort
description	Loss-of-function mutations in TBK1 have been identified in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Van Mossevelde et al. compare TBK1-mutation carriers with FTD, ALS or FTD-ALS to patients carrying GRN or C9orf72 mutations. Differences are seen in age of onset, extrapyramidal symptoms, and in memory, language and behaviour.
publisher	Oxford University Press
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805085/
_version_	1613556885056651264

Clinical features of TBK1 carriers compared with C9orf72, GRN and non-mutation carriers in a Belgian cohort

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