Small Heterodimer Partner and Innate Immune Regulation
The nuclear receptor superfamily consists of the steroid and non-steroid hormone receptors and the orphan nuclear receptors. Small heterodimer partner (SHP) is an orphan family nuclear receptor that plays an essential role in the regulation of glucose and cholesterol metabolism. Recent studies repor...
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Korean Endocrine Society
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803555/ |
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pubmed-48035552016-03-27 Small Heterodimer Partner and Innate Immune Regulation Yuk, Jae-Min Jin, Hyo Sun Jo, Eun-Kyeong Review Article The nuclear receptor superfamily consists of the steroid and non-steroid hormone receptors and the orphan nuclear receptors. Small heterodimer partner (SHP) is an orphan family nuclear receptor that plays an essential role in the regulation of glucose and cholesterol metabolism. Recent studies reported a previously unidentified role for SHP in the regulation of innate immunity and inflammation. The innate immune system has a critical function in the initial response against a variety of microbial and danger signals. Activation of the innate immune response results in the induction of inflammatory cytokines and chemokines to promote anti-microbial effects. An excessive or uncontrolled inflammatory response is potentially harmful to the host, and can cause tissue damage or pathological threat. Therefore, the innate immune response should be tightly regulated to enhance host defense while preventing unwanted immune pathologic responses. In this review, we discuss recent studies showing that SHP is involved in the negative regulation of toll-like receptor-induced and NLRP3 (NACHT, LRR and PYD domains-containing protein 3)-mediated inflammatory responses in innate immune cells. Understanding the function of SHP in innate immune cells will allow us to prevent or modulate acute and chronic inflammation processes in cases where dysregulated innate immune activation results in damage to normal tissues. Korean Endocrine Society 2016-03 2016-03-16 /pmc/articles/PMC4803555/ /pubmed/26754583 http://dx.doi.org/10.3803/EnM.2016.31.1.17 Text en Copyright © 2016 Korean Endocrine Society http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Yuk, Jae-Min Jin, Hyo Sun Jo, Eun-Kyeong |
| spellingShingle |
Yuk, Jae-Min Jin, Hyo Sun Jo, Eun-Kyeong Small Heterodimer Partner and Innate Immune Regulation |
| author_facet |
Yuk, Jae-Min Jin, Hyo Sun Jo, Eun-Kyeong |
| author_sort |
Yuk, Jae-Min |
| title |
Small Heterodimer Partner and Innate Immune Regulation |
| title_short |
Small Heterodimer Partner and Innate Immune Regulation |
| title_full |
Small Heterodimer Partner and Innate Immune Regulation |
| title_fullStr |
Small Heterodimer Partner and Innate Immune Regulation |
| title_full_unstemmed |
Small Heterodimer Partner and Innate Immune Regulation |
| title_sort |
small heterodimer partner and innate immune regulation |
| description |
The nuclear receptor superfamily consists of the steroid and non-steroid hormone receptors and the orphan nuclear receptors. Small heterodimer partner (SHP) is an orphan family nuclear receptor that plays an essential role in the regulation of glucose and cholesterol metabolism. Recent studies reported a previously unidentified role for SHP in the regulation of innate immunity and inflammation. The innate immune system has a critical function in the initial response against a variety of microbial and danger signals. Activation of the innate immune response results in the induction of inflammatory cytokines and chemokines to promote anti-microbial effects. An excessive or uncontrolled inflammatory response is potentially harmful to the host, and can cause tissue damage or pathological threat. Therefore, the innate immune response should be tightly regulated to enhance host defense while preventing unwanted immune pathologic responses. In this review, we discuss recent studies showing that SHP is involved in the negative regulation of toll-like receptor-induced and NLRP3 (NACHT, LRR and PYD domains-containing protein 3)-mediated inflammatory responses in innate immune cells. Understanding the function of SHP in innate immune cells will allow us to prevent or modulate acute and chronic inflammation processes in cases where dysregulated innate immune activation results in damage to normal tissues. |
| publisher |
Korean Endocrine Society |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803555/ |
| _version_ |
1613556353101463552 |