The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model

The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model

Dysregulated expression of miR-219, a brain-specific microRNA, has been observed in neurodevelopmental disorders, such as schizophrenia (SCZ). However, its role in normal mammalian neural stem cells (NSCs) and in SCZ pathogenesis remains unknown. We show here that the nuclear receptor TLX, an essent...

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Bibliographic Details
Main Authors: Murai, Kiyohito, Sun, Guoqiang, Ye, Peng, Tian, E., Yang, Su, Cui, Qi, Sun, Guihua, Trinh, Daniel, Sun, Olivia, Hong, Teresa, Wen, Zhexing, Kalkum, Markus, Riggs, Arthur D., Song, Hongjun, Ming, Guo-li, Shi, Yanhong
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793043/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793043/

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