Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis

Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis

Glioblastomas have been proposed to be maintained by highly tumorigenic glioblastoma stem cells (GSCs) that are resistant to current therapy. Therefore, targeting GSCs is critical for developing effective therapies for glioblastoma. In this study, we identify the regulatory cascade of the nuclear re...

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Bibliographic Details
Main Authors: Cui, Qi, Yang, Su, Ye, Peng, Tian, E., Sun, Guoqiang, Zhou, Jiehua, Sun, Guihua, Liu, Xiaoxuan, Chen, Chao, Murai, Kiyohito, Zhao, Chunnian, Azizian, Krist T., Yang, Lu, Warden, Charles, Wu, Xiwei, D'Apuzzo, Massimo, Brown, Christine, Badie, Behnam, Peng, Ling, Riggs, Arthur D., Rossi, John J., Shi, Yanhong
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742843/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742843/

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