Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1

Synaptotagmin (syt)-1 is a Ca2+ sensor that triggers rapid synaptic vesicle exocytosis. Mutations that disrupt physical interactions between the tandem Ca2+-sensing modules (C2 domains) of syt-1 disrupt regulated membrane fusion in reconstituted fusion reactions and in neurons. Hence contacts betwee...

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Main Authors:	Evans, Chantell S., He, Zixuan, Bai, Hua, Lou, Xiaochu, Jeggle, Pia, Sutton, R. Bryan, Edwardson, J. Michael, Chapman, Edwin R.
Format:	Online
Language:	English
Published:	The American Society for Cell Biology 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791141/

id	pubmed-4791141
recordtype	oai_dc
spelling	pubmed-47911412016-05-30 Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1 Evans, Chantell S. He, Zixuan Bai, Hua Lou, Xiaochu Jeggle, Pia Sutton, R. Bryan Edwardson, J. Michael Chapman, Edwin R. Articles Synaptotagmin (syt)-1 is a Ca2+ sensor that triggers rapid synaptic vesicle exocytosis. Mutations that disrupt physical interactions between the tandem Ca2+-sensing modules (C2 domains) of syt-1 disrupt regulated membrane fusion in reconstituted fusion reactions and in neurons. Hence contacts between these domains are important for function. The American Society for Cell Biology 2016-03-15 /pmc/articles/PMC4791141/ /pubmed/26792839 http://dx.doi.org/10.1091/mbc.E15-07-0503 Text en © 2016 Evans et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Evans, Chantell S. He, Zixuan Bai, Hua Lou, Xiaochu Jeggle, Pia Sutton, R. Bryan Edwardson, J. Michael Chapman, Edwin R.
spellingShingle	Evans, Chantell S. He, Zixuan Bai, Hua Lou, Xiaochu Jeggle, Pia Sutton, R. Bryan Edwardson, J. Michael Chapman, Edwin R. Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1
author_facet	Evans, Chantell S. He, Zixuan Bai, Hua Lou, Xiaochu Jeggle, Pia Sutton, R. Bryan Edwardson, J. Michael Chapman, Edwin R.
author_sort	Evans, Chantell S.
title	Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1
title_short	Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1
title_full	Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1
title_fullStr	Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1
title_full_unstemmed	Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1
title_sort	functional analysis of the interface between the tandem c2 domains of synaptotagmin-1
description	Synaptotagmin (syt)-1 is a Ca2+ sensor that triggers rapid synaptic vesicle exocytosis. Mutations that disrupt physical interactions between the tandem Ca2+-sensing modules (C2 domains) of syt-1 disrupt regulated membrane fusion in reconstituted fusion reactions and in neurons. Hence contacts between these domains are important for function.
publisher	The American Society for Cell Biology
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791141/
_version_	1613551557689737216

Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1

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