Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1
Synaptotagmin (syt)-1 is a Ca2+ sensor that triggers rapid synaptic vesicle exocytosis. Mutations that disrupt physical interactions between the tandem Ca2+-sensing modules (C2 domains) of syt-1 disrupt regulated membrane fusion in reconstituted fusion reactions and in neurons. Hence contacts betwee...
| Main Authors: | , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The American Society for Cell Biology
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791141/ |