Role of Biomarkers in the Development of PARP Inhibitors

Defects in DNA repair lead to genomic instability and play a critical role in cancer development. Understanding the process by which DNA damage repair is altered or bypassed in cancer may identify novel therapeutic targets and lead to improved patient outcomes. Poly(adenosine diphosphate-ribose) pol...

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Bibliographic Details
Main Authors: Ganguly, Bratati, Dolfi, Sonia C., Rodriguez-Rodriguez, Lorna, Ganesan, Shridar, Hirshfield, Kim M.
Format: Online
Language:English
Published: Libertas Academica 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786099/