PARP inhibitors: its role in treatment of cancer
PARP is an important protein in DNA repair pathways especially the base excision repair (BER). BER is involved in DNA repair of single strand breaks (SSBs). If BER is impaired, inhibiting poly(ADP-ribose) polymerase (PARP), SSBs accumulate and become double stand breaks (DSBs). The cells with increa...
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| Format: | Online |
| Language: | English |
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Sun Yat-sen University Cancer Center
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013421/ |