Epithelial–mesenchymal transition, IP3 receptors and ER–PM junctions: translocation of Ca2+ signalling complexes and regulation of migration

Epithelial–mesenchymal transition, IP3 receptors and ER–PM junctions: translocation of Ca2+ signalling complexes and regulation of migration

During epithelial–mesenchymal transition IP3Rs relocate from tight junctions to the leading edge of migrating pancreatic cancer cells and regulate dynamics of focal adhesions. STIM1-competent ER–PM junctions position closely behind IP3Rs and, together with IP3Rs, regulate cell migration.

Bibliographic Details
Main Authors: Okeke, Emmanuel, Parker, Tony, Dingsdale, Hayley, Concannon, Matthew, Awais, Muhammad, Voronina, Svetlana, Molgó, Jordi, Begg, Malcolm, Metcalf, Daniel, Knight, Alex E., Sutton, Robert, Haynes, Lee, Tepikin, Alexei V.
Format: Online
Language:English
Published: Portland Press Ltd. 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785603/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785603/

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