Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies

Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies

Replication errors are the main cause of mitochondrial DNA (mtDNA) mutations and a compelling approach to decrease mutation levels would therefore be to increase the fidelity of the catalytic subunit (POLγA) of the mtDNA polymerase. Here we genomically engineer the tamas locus, encoding fly POLγA, a...

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Bibliographic Details
Main Authors: Bratic, Ana, Kauppila, Timo E. S., Macao, Bertil, Grönke, Sebastian, Siibak, Triinu, Stewart, James B., Baggio, Francesca, Dols, Jacqueline, Partridge, Linda, Falkenberg, Maria, Wredenberg, Anna, Larsson, Nils-Göran
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773887/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773887/

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