The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication

The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication

Mitochondrial DNA (mtDNA) polymerase γ (POLγ) harbours a 3′–5′ exonuclease proofreading activity. Here we demonstrate that this activity is required for the creation of ligatable ends during mtDNA replication. Exonuclease-deficient POLγ fails to pause on reaching a downstream 5′-end. Instead, the en...

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Bibliographic Details
Main Authors: Macao, Bertil, Uhler, Jay P., Siibak, Triinu, Zhu, Xuefeng, Shi, Yonghong, Sheng, Wenwen, Olsson, Monica, Stewart, James B., Gustafsson, Claes M., Falkenberg, Maria
Format: Online
Language:English
Published: Nature Pub. Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557304/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557304/

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