N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin

N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin

Neprilysin (NEP) and endothelin converting enzyme-1 (ECE-1) are two enzymes that degrade amyloid beta in the brain. Currently there are no molecules to stimulate the activity of these enzymes. Here we report, the discovery and characterisation of a peptide referred to as K49-P1-20, from the venom of...

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Bibliographic Details
Main Authors: Smith, A. Ian, Rajapakse, Niwanthi W., Kleifeld, Oded, Lomonte, Bruno, Sikanyika, Nkumbu L., Spicer, Alexander J., Hodgson, Wayne C., Conroy, Paul J., Small, David H., Kaye, David M., Parkington, Helena C., Whisstock, James C., Kuruppu, Sanjaya
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773759/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773759/

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