A Lys49-PLA2 myotoxin of Bothrops asper triggers a rapid death of macrophages that involves autocrine purinergic receptor signaling

A Lys49-PLA2 myotoxin of Bothrops asper triggers a rapid death of macrophages that involves autocrine purinergic receptor signaling

Lys49-PLA2 myotoxins, an important component of various viperid snake venoms, are a class of PLA2-homolog proteins deprived of catalytic activity. Similar to enzymatically active PLA2 (Asp49) and to other classes of myotoxins, they cause severe myonecrosis. Moreover, these toxins are used as tools t...

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Bibliographic Details
Main Authors: Tonello, F, Simonato, M, Aita, A, Pizzo, P, Fernández, J, Lomonte, B, Gutiérrez, J M, Montecucco, C
Format: Online
Language:English
Published: Nature Publishing Group 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406575/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406575/

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