Impaired Inactivation of L-Type Ca2+ Current as a Potential Mechanism for Variable Arrhythmogenic Liability of HERG K+ Channel Blocking Drugs

Impaired Inactivation of L-Type Ca2+ Current as a Potential Mechanism for Variable Arrhythmogenic Liability of HERG K+ Channel Blocking Drugs

The proarrhythmic effects of new drugs have been assessed by measuring rapidly activating delayed-rectifier K+ current (IKr) antagonist potency. However, recent data suggest that even drugs thought to be highly specific IKr blockers can be arrhythmogenic via a separate, time-dependent pathway such a...

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Bibliographic Details
Main Authors: Kim, Jae Gon, Sung, Dong Jun, Kim, Hyun-ji, Park, Sang Woong, Won, Kyung Jong, Kim, Bokyung, Shin, Ho Chul, Kim, Ki-Suk, Leem, Chae Hun, Zhang, Yin Hua, Cho, Hana, Bae, Young Min
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772914/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772914/

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