Na+ Permeation and Block of hERG Potassium Channels
The inactivation gating of hERG channels is important for the channel function and drug–channel interaction. Whereas hERG channels are highly selective for K+, we have found that inactivated hERG channels allow Na+ to permeate in the absence of K+. This provides a new way to directly monitor and inv...
| Main Authors: | , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
2006
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151557/ |