A Common Variant in the SETD7 Gene Predicts Serum Lycopene Concentrations

Dietary intake and higher serum concentrations of lycopene have been associated with lower incidence of prostate cancer and other chronic diseases. Identifying determinants of serum lycopene concentrations may thus have important public health implications. Prior studies have suggested that serum ly...

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Main Authors:	D’Adamo, Christopher R., D’Urso, Antonietta, Ryan, Kathleen A., Yerges-Armstrong, Laura M., Semba, Richard D., Steinle, Nanette I., Mitchell, Braxton D., Shuldiner, Alan R., McArdle, Patrick F.
Format:	Online
Language:	English
Published:	MDPI 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772045/

id	pubmed-4772045
recordtype	oai_dc
spelling	pubmed-47720452016-03-08 A Common Variant in the SETD7 Gene Predicts Serum Lycopene Concentrations D’Adamo, Christopher R. D’Urso, Antonietta Ryan, Kathleen A. Yerges-Armstrong, Laura M. Semba, Richard D. Steinle, Nanette I. Mitchell, Braxton D. Shuldiner, Alan R. McArdle, Patrick F. Article Dietary intake and higher serum concentrations of lycopene have been associated with lower incidence of prostate cancer and other chronic diseases. Identifying determinants of serum lycopene concentrations may thus have important public health implications. Prior studies have suggested that serum lycopene concentrations are under partial genetic control. The goal of this research was to identify genetic predictors of serum lycopene concentrations using the genome-wide association study (GWAS) approach among a sample of 441 Old Order Amish adults that consumed a controlled diet. Linear regression models were utilized to evaluate associations between genetic variants and serum concentrations of lycopene. Variant rs7680948 on chromosome 4, located in the intron region of the SETD7 gene, was significantly associated with serum lycopene concentrations (p = 3.41 × 10−9). Our findings also provided nominal support for the association previously noted between SCARB1 and serum lycopene concentrations, although with a different SNP (rs11057841) in the region. This study identified a novel locus associated with serum lycopene concentrations and our results raise a number of intriguing possibilities regarding the nature of the relationship between SETD7 and lycopene, both of which have been independently associated with prostate cancer. Further investigation into this relationship might help provide greater mechanistic understanding of these associations. MDPI 2016-02-06 /pmc/articles/PMC4772045/ /pubmed/26861389 http://dx.doi.org/10.3390/nu8020082 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	D’Adamo, Christopher R. D’Urso, Antonietta Ryan, Kathleen A. Yerges-Armstrong, Laura M. Semba, Richard D. Steinle, Nanette I. Mitchell, Braxton D. Shuldiner, Alan R. McArdle, Patrick F.
spellingShingle	D’Adamo, Christopher R. D’Urso, Antonietta Ryan, Kathleen A. Yerges-Armstrong, Laura M. Semba, Richard D. Steinle, Nanette I. Mitchell, Braxton D. Shuldiner, Alan R. McArdle, Patrick F. A Common Variant in the SETD7 Gene Predicts Serum Lycopene Concentrations
author_facet	D’Adamo, Christopher R. D’Urso, Antonietta Ryan, Kathleen A. Yerges-Armstrong, Laura M. Semba, Richard D. Steinle, Nanette I. Mitchell, Braxton D. Shuldiner, Alan R. McArdle, Patrick F.
author_sort	D’Adamo, Christopher R.
title	A Common Variant in the SETD7 Gene Predicts Serum Lycopene Concentrations
title_short	A Common Variant in the SETD7 Gene Predicts Serum Lycopene Concentrations
title_full	A Common Variant in the SETD7 Gene Predicts Serum Lycopene Concentrations
title_fullStr	A Common Variant in the SETD7 Gene Predicts Serum Lycopene Concentrations
title_full_unstemmed	A Common Variant in the SETD7 Gene Predicts Serum Lycopene Concentrations
title_sort	common variant in the setd7 gene predicts serum lycopene concentrations
description	Dietary intake and higher serum concentrations of lycopene have been associated with lower incidence of prostate cancer and other chronic diseases. Identifying determinants of serum lycopene concentrations may thus have important public health implications. Prior studies have suggested that serum lycopene concentrations are under partial genetic control. The goal of this research was to identify genetic predictors of serum lycopene concentrations using the genome-wide association study (GWAS) approach among a sample of 441 Old Order Amish adults that consumed a controlled diet. Linear regression models were utilized to evaluate associations between genetic variants and serum concentrations of lycopene. Variant rs7680948 on chromosome 4, located in the intron region of the SETD7 gene, was significantly associated with serum lycopene concentrations (p = 3.41 × 10−9). Our findings also provided nominal support for the association previously noted between SCARB1 and serum lycopene concentrations, although with a different SNP (rs11057841) in the region. This study identified a novel locus associated with serum lycopene concentrations and our results raise a number of intriguing possibilities regarding the nature of the relationship between SETD7 and lycopene, both of which have been independently associated with prostate cancer. Further investigation into this relationship might help provide greater mechanistic understanding of these associations.
publisher	MDPI
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772045/
_version_	1613545076205551616

A Common Variant in the SETD7 Gene Predicts Serum Lycopene Concentrations

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