Association of the EGF-TM7 receptor CD97 expression with FLT3-ITD in acute myeloid leukemia

Association of the EGF-TM7 receptor CD97 expression with FLT3-ITD in acute myeloid leukemia

Internal tandem duplications within the juxtamembrane region of the FMS-like tyrosine kinase receptor FLT3 (FLT3-ITD) represents one of the most common mutations in patients with acute myeloid leukemia (AML) which results in constitutive aberrant activation, increased proliferation of leukemic proge...

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Main Authors: Wobus, Manja, Bornhäuser, Martin, Jacobi, Angela, Kräter, Martin, Otto, Oliver, Ortlepp, Claudia, Guck, Jochen, Ehninger, Gerhard, Thiede, Christian, Oelschlägel, Uta
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770738/
id pubmed-4770738
recordtype oai_dc
spelling pubmed-47707382016-03-21 Association of the EGF-TM7 receptor CD97 expression with FLT3-ITD in acute myeloid leukemia Wobus, Manja Bornhäuser, Martin Jacobi, Angela Kräter, Martin Otto, Oliver Ortlepp, Claudia Guck, Jochen Ehninger, Gerhard Thiede, Christian Oelschlägel, Uta Research Paper Internal tandem duplications within the juxtamembrane region of the FMS-like tyrosine kinase receptor FLT3 (FLT3-ITD) represents one of the most common mutations in patients with acute myeloid leukemia (AML) which results in constitutive aberrant activation, increased proliferation of leukemic progenitors and is associated with an aggressive clinical phenotype. The expression of CD97, an EGF-TM7 receptor, has been linked to invasive behavior in thyroid and colorectal cancer. Here, we have investigated the association of CD97 with FLT3-ITD and its functional consequences in AML. Impact Journals LLC 2015-10-07 /pmc/articles/PMC4770738/ /pubmed/26462154 Text en Copyright: © 2015 Wobus et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Wobus, Manja
Bornhäuser, Martin
Jacobi, Angela
Kräter, Martin
Otto, Oliver
Ortlepp, Claudia
Guck, Jochen
Ehninger, Gerhard
Thiede, Christian
Oelschlägel, Uta
spellingShingle Wobus, Manja
Bornhäuser, Martin
Jacobi, Angela
Kräter, Martin
Otto, Oliver
Ortlepp, Claudia
Guck, Jochen
Ehninger, Gerhard
Thiede, Christian
Oelschlägel, Uta
Association of the EGF-TM7 receptor CD97 expression with FLT3-ITD in acute myeloid leukemia
author_facet Wobus, Manja
Bornhäuser, Martin
Jacobi, Angela
Kräter, Martin
Otto, Oliver
Ortlepp, Claudia
Guck, Jochen
Ehninger, Gerhard
Thiede, Christian
Oelschlägel, Uta
author_sort Wobus, Manja
title Association of the EGF-TM7 receptor CD97 expression with FLT3-ITD in acute myeloid leukemia
title_short Association of the EGF-TM7 receptor CD97 expression with FLT3-ITD in acute myeloid leukemia
title_full Association of the EGF-TM7 receptor CD97 expression with FLT3-ITD in acute myeloid leukemia
title_fullStr Association of the EGF-TM7 receptor CD97 expression with FLT3-ITD in acute myeloid leukemia
title_full_unstemmed Association of the EGF-TM7 receptor CD97 expression with FLT3-ITD in acute myeloid leukemia
title_sort association of the egf-tm7 receptor cd97 expression with flt3-itd in acute myeloid leukemia
description Internal tandem duplications within the juxtamembrane region of the FMS-like tyrosine kinase receptor FLT3 (FLT3-ITD) represents one of the most common mutations in patients with acute myeloid leukemia (AML) which results in constitutive aberrant activation, increased proliferation of leukemic progenitors and is associated with an aggressive clinical phenotype. The expression of CD97, an EGF-TM7 receptor, has been linked to invasive behavior in thyroid and colorectal cancer. Here, we have investigated the association of CD97 with FLT3-ITD and its functional consequences in AML.
publisher Impact Journals LLC
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770738/
_version_ 1613544656503570432

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