Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3' regulatory region

Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3' regulatory region

The IgH 3' regulatory region (3'RR) controls class switch recombination (CSR) and somatic hypermutation (SHM) in B cells. The mouse 3'RR contains four enhancer elements with hs1,2 flanked by inverted repeated sequences and the centre of a 25-kb palindrome bounded by two hs3 enhancer i...

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Bibliographic Details
Main Authors: Saintamand, Alexis, Vincent-Fabert, Christelle, Garot, Armand, Rouaud, Pauline, Oruc, Zeliha, Magnone, Virginie, Cogné, Michel, Denizot, Yves
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757795/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757795/

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