The IgH 3′ regulatory region governs μ chain transcription in mature B lymphocytes and the B cell fate

The IgH 3′ regulatory region governs μ chain transcription in mature B lymphocytes and the B cell fate

We report that the IgH 3′ regulatory region (3′RR) has no role on μ chain transcription and pre-BCR expression in B cell progenitors. In contrast, analysis of heterozygous IgH aΔ3′RR/bwt mice indicated that the 3′RR controls μ chain transcripts in mature splenocytes and impacts membrane IgM density...

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Bibliographic Details
Main Authors: Saintamand, Alexis, Rouaud, Pauline, Garot, Armand, Saad, Faten, Carrion, Claire, Oblet, Christelle, Cogné, Michel, Pinaud, Eric, Denizot, Yves
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467119/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467119/

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