A novel high-throughput activity assay for the Trypanosoma brucei editosome enzyme REL1 and other RNA ligases

The protist parasite Trypanosoma brucei causes Human African trypanosomiasis (HAT), which threatens millions of people in sub-Saharan Africa. Without treatment the infection is almost always lethal. Current drugs for HAT are difficult to administer and have severe side effects. Together with increas...

Full description

Bibliographic Details
Main Authors: Zimmermann, Stephan, Hall, Laurence, Riley, Sean, Sørensen, Jesper, Amaro, Rommie E., Schnaufer, Achim
Format: Online
Language:English
Published: Oxford University Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756849/