Mitochondrial DNA is critical for longevity and metabolism of transmission stage Trypanosoma brucei.

The sleeping sickness parasite Trypanosoma brucei has a complex life cycle, alternating between a mammalian host and the tsetse fly vector. A tightly controlled developmental programme ensures parasite transmission between hosts as well as survival within them and involves strict regulation of mitoc...

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Bibliographic Details
Main Authors: Caroline E Dewar, Paula MacGregor, Sinclair Cooper, Matthew K Gould, Keith R Matthews, Nicholas J Savill, Achim Schnaufer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-07-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC6066258?pdf=render