HIV coreceptor tropism determination and mutational pattern identification

In the early stages of infection, Human Immunodeficiency Virus Type 1 (HIV-1) generally selects CCR5 as the primary coreceptor for entering the host cell. As infection progresses, the virus evolves and may exhibit a coreceptor-switch to CXCR4. Accurate determination coreceptor usage and identificati...

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Bibliographic Details
Main Authors: Shen, Hui-Shuang, Yin, Jason, Leng, Fei, Teng, Rui-Fang, Xu, Chao, Xia, Xia-Yu, Pan, Xian-Ming
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756667/