Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis

Peritoneal dialysis is a form of renal replacement alternative to the hemodialysis. During this treatment, the peritoneal membrane acts as a permeable barrier for exchange of solutes and water. Continual exposure to dialysis solutions, as well as episodes of peritonitis and hemoperitoneum, can cause...

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Main Authors:	Strippoli, Raffaele, Moreno-Vicente, Roberto, Battistelli, Cecilia, Cicchini, Carla, Noce, Valeria, Amicone, Laura, Marchetti, Alessandra, del Pozo, Miguel Angel, Tripodi, Marco
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752998/

id	pubmed-4752998
recordtype	oai_dc
spelling	pubmed-47529982016-03-03 Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis Strippoli, Raffaele Moreno-Vicente, Roberto Battistelli, Cecilia Cicchini, Carla Noce, Valeria Amicone, Laura Marchetti, Alessandra del Pozo, Miguel Angel Tripodi, Marco Review Article Peritoneal dialysis is a form of renal replacement alternative to the hemodialysis. During this treatment, the peritoneal membrane acts as a permeable barrier for exchange of solutes and water. Continual exposure to dialysis solutions, as well as episodes of peritonitis and hemoperitoneum, can cause acute/chronic inflammation and injury to the peritoneal membrane, which undergoes progressive fibrosis, angiogenesis, and vasculopathy, eventually leading to discontinuation of the peritoneal dialysis. Among the different events controlling this pathological process, epithelial to mesenchymal transition of mesothelial cells plays a main role in the induction of fibrosis and in subsequent functional deterioration of the peritoneal membrane. Here, the main extracellular inducers and cellular players are described. Moreover, signaling pathways acting during this process are elucidated, with emphasis on signals delivered by TGF-β family members and by Toll-like/IL-1β receptors. The understanding of molecular mechanisms underlying fibrosis of the peritoneal membrane has both a basic and a translational relevance, since it may be useful for setup of therapies aimed at counteracting the deterioration as well as restoring the homeostasis of the peritoneal membrane. Hindawi Publishing Corporation 2016 2016-01-31 /pmc/articles/PMC4752998/ /pubmed/26941801 http://dx.doi.org/10.1155/2016/3543678 Text en Copyright © 2016 Raffaele Strippoli et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Strippoli, Raffaele Moreno-Vicente, Roberto Battistelli, Cecilia Cicchini, Carla Noce, Valeria Amicone, Laura Marchetti, Alessandra del Pozo, Miguel Angel Tripodi, Marco
spellingShingle	Strippoli, Raffaele Moreno-Vicente, Roberto Battistelli, Cecilia Cicchini, Carla Noce, Valeria Amicone, Laura Marchetti, Alessandra del Pozo, Miguel Angel Tripodi, Marco Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis
author_facet	Strippoli, Raffaele Moreno-Vicente, Roberto Battistelli, Cecilia Cicchini, Carla Noce, Valeria Amicone, Laura Marchetti, Alessandra del Pozo, Miguel Angel Tripodi, Marco
author_sort	Strippoli, Raffaele
title	Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis
title_short	Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis
title_full	Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis
title_fullStr	Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis
title_full_unstemmed	Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis
title_sort	molecular mechanisms underlying peritoneal emt and fibrosis
description	Peritoneal dialysis is a form of renal replacement alternative to the hemodialysis. During this treatment, the peritoneal membrane acts as a permeable barrier for exchange of solutes and water. Continual exposure to dialysis solutions, as well as episodes of peritonitis and hemoperitoneum, can cause acute/chronic inflammation and injury to the peritoneal membrane, which undergoes progressive fibrosis, angiogenesis, and vasculopathy, eventually leading to discontinuation of the peritoneal dialysis. Among the different events controlling this pathological process, epithelial to mesenchymal transition of mesothelial cells plays a main role in the induction of fibrosis and in subsequent functional deterioration of the peritoneal membrane. Here, the main extracellular inducers and cellular players are described. Moreover, signaling pathways acting during this process are elucidated, with emphasis on signals delivered by TGF-β family members and by Toll-like/IL-1β receptors. The understanding of molecular mechanisms underlying fibrosis of the peritoneal membrane has both a basic and a translational relevance, since it may be useful for setup of therapies aimed at counteracting the deterioration as well as restoring the homeostasis of the peritoneal membrane.
publisher	Hindawi Publishing Corporation
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752998/
_version_	1613538353478631424

Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis

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