A brain slice experimental model to study the generation and the propagation of focally-induced epileptiform activity

A brain slice experimental model to study the generation and the propagation of focally-induced epileptiform activity

•We propose a model of seizure-like events in temporal cortex slices from young mice.•In the model local NMDA stimulations induce multiple seizure-like events.•Electrophysiological, Ca2+ imaging and optogenetics are combined in the model.•Seizures generation and propagation are separately studied.•T...

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Bibliographic Details
Main Authors: Losi, Gabriele, Marcon, Iacopo, Mariotti, Letizia, Sessolo, Michele, Chiavegato, Angela, Carmignoto, Giorgio
Format: Online
Language:English
Published: Elsevier/North-Holland Biomedical Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751973/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751973/

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