Starvation Induces Proteasome Autophagy with Different Pathways for Core and Regulatory Particles*

The proteasome is responsible for the degradation of many cellular proteins. If and how this abundant and normally stable complex is degraded by cells is largely unknown. Here we show that in yeast, upon nitrogen starvation, proteasomes are targeted for vacuolar degradation through autophagy. Using...

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Bibliographic Details
Main Authors: Waite, Kenrick A., Mota-Peynado, Alina De-La, Vontz, Gabrielle, Roelofs, Jeroen
Format: Online
Language:English
Published: American Society for Biochemistry and Molecular Biology 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751371/