Sequestration and Red Cell Deformability as Determinants of Hyperlactatemia in Falciparum Malaria

Sequestration and Red Cell Deformability as Determinants of Hyperlactatemia in Falciparum Malaria

Background. Hyperlactatemia is a strong predictor of mortality in severe falciparum malaria. Sequestered parasitized erythrocytes and reduced uninfected red blood cell deformability (RCD) compromise microcirculatory flow, leading to anaerobic glycolysis.

Bibliographic Details
Main Authors: Ishioka, Haruhiko, Ghose, Aniruddha, Charunwatthana, Prakaykaew, Maude, Richard, Plewes, Katherine, Kingston, Hugh, Intharabut, Benjamas, Woodrow, Charlie, Chotivanich, Kesinee, Sayeed, Abdullah Abu, Hasan, Mahtab Uddin, Day, Nicholas P., Faiz, Abul, White, Nicholas J., Hossain, Amir, Dondorp, Arjen M.
Format: Online
Language:English
Published: Oxford University Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747623/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747623/

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