A novel chemical, STF-083010, reverses tamoxifen-related drug resistance in breast cancer by inhibiting IRE1/XBP1

A novel chemical, STF-083010, reverses tamoxifen-related drug resistance in breast cancer by inhibiting IRE1/XBP1

Recent studies show that the unfolded protein response (UPR) within the endoplasmic reticulum is correlated with breast cancer drug resistance. In particular, human X-box binding protein-1(XBP1), a transcription factor which participates in UPR stress signaling, is reported to correlate with poor cl...

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Bibliographic Details
Main Authors: Ming, Jie, Ruan, Shengnan, Wang, Mengyi, Ye, Dan, Fan, Ningning, Meng, Qingyu, Tian, Bo, Huang, Tao
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747362/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747362/

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