Identification of Doxorubicin as an Inhibitor of the IRE1α-XBP1 Axis of the Unfolded Protein Response

Identification of Doxorubicin as an Inhibitor of the IRE1α-XBP1 Axis of the Unfolded Protein Response

Activation of the IRE1α-XBP1 branch of the unfolded protein response (UPR) has been implicated in multiple types of human cancers, including multiple myeloma (MM). Through an in silico drug discovery approach based on protein-compound virtual docking, we identified the anthracycline antibiotic doxor...

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Bibliographic Details
Main Authors: Jiang, Dadi, Lynch, Connor, Medeiros, Bruno C., Liedtke, Michaela, Bam, Rakesh, Tam, Arvin B., Yang, Zhifen, Alagappan, Muthuraman, Abidi, Parveen, Le, Quynh-Thu, Giaccia, Amato J., Denko, Nicholas C., Niwa, Maho, Koong, Albert C.
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025885/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025885/

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