Activated mast cells promote differentiation of B cells into effector cells

Based on the known accumulation of mast cells (MCs) in B cell-dependent inflammatory diseases, including rheumatoid arthritis, we hypothesized that MCs directly modulate B cells. We show here that degranulated, and to a lesser extent naïve or IgE-sensitized, MCs activate both naïve and B cell recept...

Full description

Bibliographic Details
Main Authors: Palm, Anna-Karin E., Garcia-Faroldi, Gianni, Lundberg, Marcus, Pejler, Gunnar, Kleinau, Sandra
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742803/