Auranofin induces apoptosis by ROS-mediated ER stress and mitochondrial dysfunction and displayed synergistic lethality with piperlongumine in gastric cancer

Auranofin induces apoptosis by ROS-mediated ER stress and mitochondrial dysfunction and displayed synergistic lethality with piperlongumine in gastric cancer

Gastric cancer (GC) is one of the leading causes of cancer mortality in the world. In addressing the need of treatments for relapsed disease, we report the identification of an existing U.S. Food and Drug Administration-approved small-molecule drug to repurpose for GC treatment. Auranofin (AF), clin...

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Bibliographic Details
Main Authors: Zou, Peng, Chen, Minxiao, Ji, Jiansong, Chen, Weiqian, Chen, Xi, Ying, Shilong, Zhang, Junru, Zhang, Ziheng, Liu, Zhiguo, Yang, Shulin, Liang, Guang
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742192/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742192/

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