Active YAP promotes pancreatic cancer cell motility, invasion and tumorigenesis in a mitotic phosphorylation-dependent manner through LPAR3

Active YAP promotes pancreatic cancer cell motility, invasion and tumorigenesis in a mitotic phosphorylation-dependent manner through LPAR3

The transcriptional co-activator Yes-associated protein, YAP, is a main effector in the Hippo tumor suppressor pathway. We recently defined a mechanism for positive regulation of YAP through CDK1-mediated mitotic phosphorylation. Here, we show that active YAP promotes pancreatic cancer cell migratio...

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Bibliographic Details
Main Authors: Yang, Shuping, Zhang, Lin, Purohit, Vinee, Shukla, Surendra K., Chen, Xingcheng, Yu, Fang, Fu, Kai, Chen, Yuanhong, Solheim, Joyce, Singh, Pankaj K., Song, Wei, Dong, Jixin
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742158/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742158/

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