B5, a thioredoxin reductase inhibitor, induces apoptosis in human cervical cancer cells by suppressing the thioredoxin system, disrupting mitochondrion-dependent pathways and triggering autophagy

B5, a thioredoxin reductase inhibitor, induces apoptosis in human cervical cancer cells by suppressing the thioredoxin system, disrupting mitochondrion-dependent pathways and triggering autophagy

The synthetic curcumin analog B5 is a potent inhibitor of thioredoxin reductase (TrxR) that has potential anticancer effects. The molecular mechanism underlying B5 as an anticancer agent is not yet fully understood. In this study, we report that B5 induces apoptosis in two human cervical cancer cell...

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Bibliographic Details
Main Authors: Shao, Fang-Yuan, Du, Zhi-Yun, Ma, Dong-Lei, Chen, Wen-Bo, Fu, Wu-Yu, Ruan, Bi-Bo, Rui, Wen, Zhang, Jia-Xuan, Wang, Sheng, Wong, Nai Sum, Xiao, Hao, Li, Man-Mei, Liu, Xiao, Liu, Qiu-Ying, Zhou, Xiao-dong, Yan, Hai-Zhao, Wang, Yi-Fei, Chen, Chang-Yan, Liu, Zhong, Chen, Hong-Yuan
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741579/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741579/

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