UHRF1 regulation of the Keap1–Nrf2 pathway in pancreatic cancer contributes to oncogenesis

UHRF1 regulation of the Keap1–Nrf2 pathway in pancreatic cancer contributes to oncogenesis

The cellular defence protein Nrf2 is a mediator of oncogenesis in pancreatic ductal adenocarcinoma (PDAC) and other cancers. However, the control of Nrf2 expression and activity in cancer is not fully understood. We previously reported the absence of Keap1, a pivotal regulator of Nrf2, in ∼70% of PD...

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Bibliographic Details
Main Authors: Abu‐Alainin, Wafa, Gana, Thompson, Liloglou, Triantafillos, Olayanju, Adedamola, Barrera, Lawrence N, Ferguson, Robert, Campbell, Fiona, Andrews, Timothy, Goldring, Christopher, Kitteringham, Neil, Park, Brian K, Nedjadi, Taoufik, Schmid, Michael C, Slupsky, Joseph R, Greenhalf, William, Neoptolemos, John P, Costello, Eithne
Format: Online
Language:English
Published: John Wiley & Sons, Ltd 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738372/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738372/

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