Structural basis of Keap1 interactions with Nrf2
Keap1 is a highly redox-sensitive member of the BTB-Kelch family that assembles with the Cul3 protein to form a Cullin–RING E3 ligase complex for the degradation of Nrf2. Oxidative stress disables Keap1, allowing Nrf2 protein levels to accumulate for the transactivation of critical stress response g...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
Elsevier Science
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668279/ |