SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication

SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication

Maintenance of genome stability requires that DNA is replicated precisely once per cell cycle. This is believed to be achieved by limiting replication origin licensing and thereby restricting the firing of each replication origin to once per cell cycle. CDC6 is essential for eukaryotic replication o...

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Bibliographic Details
Main Authors: Walter, David, Hoffmann, Saskia, Komseli, Eirini-Stavroula, Rappsilber, Juri, Gorgoulis, Vassilis, Sørensen, Claus Storgaard
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738361/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738361/

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