Cdc45 is limiting for replication initiation in humans
Cdc45 is an essential protein that together with Mcm2-7 and GINS forms the eukaryotic replicative helicase CMG. Cdc45 seems to be rate limiting for the initial unwinding or firing of replication origins. In line with this view, Cdc45-overexpressing cells fired at least twice as many origins as contr...
| Main Authors: | , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Taylor & Francis
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889307/ |