Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome

Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome

The dual-specificity tyrosine-phosphorylation-regulated kinase, DYRK1B, is expressed de novo during myogenesis, amplified or mutated in certain cancers and mutated in familial cases of metabolic syndrome. DYRK1B is activated by cis auto-phosphorylation on tyrosine-273 (Y273) within the activation lo...

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Bibliographic Details
Main Authors: Ashford, Anne L., Dunkley, Tom P. J., Cockerill, Mark, Rowlinson, Rachel A., Baak, Lisa M., Gallo, Raffaella, Balmanno, Kathryn, Goodwin, Louise M., Ward, Richard A., Lochhead, Pamela A., Guichard, Sylvie, Hudson, Kevin, Cook, Simon J.
Format: Online
Language:English
Published: Springer International Publishing 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735261/

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