α/β-Hydrolase domain-6 and saturated long chain monoacylglycerol regulate insulin secretion promoted by both fuel and non-fuel stimuli

α/β-Hydrolase domain-6 and saturated long chain monoacylglycerol regulate insulin secretion promoted by both fuel and non-fuel stimuli

•ABHD6 is the major monoacylglycerol (MAG) hydrolase in pancreatic β cells.•1-MAG level is elevated in islets from β cell specific ABHD6-KO mice (BKO).•BKO islets show enhanced fuel and non-fuel induced insulin secretion.•ABHD6 accessible 1-MAG synergizes with other signals for insulin secretion....

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Bibliographic Details
Main Authors: Zhao, Shangang, Poursharifi, Pegah, Mugabo, Yves, Levens, Emily J., Vivot, Kevin, Attane, Camille, Iglesias, Jose, Peyot, Marie-line, Joly, Erik, Madiraju, S.R. Murthy, Prentki, Marc
Format: Online
Language:English
Published: Elsevier 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731734/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731734/

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