Heme oxygenase-1 is dispensable for the anti-inflammatory activity of intravenous immunoglobulin

Intravenous immunoglobulin G (IVIG) is used in the therapy of various autoimmune and inflammatory conditions. The mechanisms by which IVIG exerts anti-inflammatory effects are not completely understood. IVIG interacts with numerous components of the immune system including dendritic cells, macrophag...

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Main Authors:	Galeotti, Caroline, Hegde, Pushpa, Das, Mrinmoy, Stephen-Victor, Emmanuel, Canale, Fernando, Muñoz, Marcos, Sharma, Varun K., Dimitrov, Jordan D., Kaveri, Srini V., Bayry, Jagadeesh
Format:	Online
Language:	English
Published:	Nature Publishing Group 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726216/

id	pubmed-4726216
recordtype	oai_dc
spelling	pubmed-47262162016-01-27 Heme oxygenase-1 is dispensable for the anti-inflammatory activity of intravenous immunoglobulin Galeotti, Caroline Hegde, Pushpa Das, Mrinmoy Stephen-Victor, Emmanuel Canale, Fernando Muñoz, Marcos Sharma, Varun K. Dimitrov, Jordan D. Kaveri, Srini V. Bayry, Jagadeesh Article Intravenous immunoglobulin G (IVIG) is used in the therapy of various autoimmune and inflammatory conditions. The mechanisms by which IVIG exerts anti-inflammatory effects are not completely understood. IVIG interacts with numerous components of the immune system including dendritic cells, macrophages, T and B cells and modulate their functions. Recent studies have reported that heme oxygenase-1 (HO-1) pathway plays an important role in the regulation of inflammatory response in several pathologies. Several therapeutic agents exert anti-inflammatory effects via induction of HO-1. Therefore, we aimed at exploring if anti-inflammatory effects of IVIG are mediated via HO-1 pathway. Confirming the previous reports, we report that IVIG exerts anti-inflammatory effects on innate cells as shown by the inhibitory effects on IL-6 and nitric oxide production and confers protection in experimental autoimmune encephalomyelitis (EAE) model. However, these effects were not associated with an induction of HO-1 either in innate cells such as monocytes, dendritic cells and macrophages or in the kidneys and liver of IVIG-treated EAE mice. Also, inhibition of endogenous HO-1 did not modify anti-inflammatory effects of IVIG. These results thus indicate that IVIG exerts anti-inflammatory effects independent of HO-1 pathway. Nature Publishing Group 2016-01-22 /pmc/articles/PMC4726216/ /pubmed/26796539 http://dx.doi.org/10.1038/srep19592 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Galeotti, Caroline Hegde, Pushpa Das, Mrinmoy Stephen-Victor, Emmanuel Canale, Fernando Muñoz, Marcos Sharma, Varun K. Dimitrov, Jordan D. Kaveri, Srini V. Bayry, Jagadeesh
spellingShingle	Galeotti, Caroline Hegde, Pushpa Das, Mrinmoy Stephen-Victor, Emmanuel Canale, Fernando Muñoz, Marcos Sharma, Varun K. Dimitrov, Jordan D. Kaveri, Srini V. Bayry, Jagadeesh Heme oxygenase-1 is dispensable for the anti-inflammatory activity of intravenous immunoglobulin
author_facet	Galeotti, Caroline Hegde, Pushpa Das, Mrinmoy Stephen-Victor, Emmanuel Canale, Fernando Muñoz, Marcos Sharma, Varun K. Dimitrov, Jordan D. Kaveri, Srini V. Bayry, Jagadeesh
author_sort	Galeotti, Caroline
title	Heme oxygenase-1 is dispensable for the anti-inflammatory activity of intravenous immunoglobulin
title_short	Heme oxygenase-1 is dispensable for the anti-inflammatory activity of intravenous immunoglobulin
title_full	Heme oxygenase-1 is dispensable for the anti-inflammatory activity of intravenous immunoglobulin
title_fullStr	Heme oxygenase-1 is dispensable for the anti-inflammatory activity of intravenous immunoglobulin
title_full_unstemmed	Heme oxygenase-1 is dispensable for the anti-inflammatory activity of intravenous immunoglobulin
title_sort	heme oxygenase-1 is dispensable for the anti-inflammatory activity of intravenous immunoglobulin
description	Intravenous immunoglobulin G (IVIG) is used in the therapy of various autoimmune and inflammatory conditions. The mechanisms by which IVIG exerts anti-inflammatory effects are not completely understood. IVIG interacts with numerous components of the immune system including dendritic cells, macrophages, T and B cells and modulate their functions. Recent studies have reported that heme oxygenase-1 (HO-1) pathway plays an important role in the regulation of inflammatory response in several pathologies. Several therapeutic agents exert anti-inflammatory effects via induction of HO-1. Therefore, we aimed at exploring if anti-inflammatory effects of IVIG are mediated via HO-1 pathway. Confirming the previous reports, we report that IVIG exerts anti-inflammatory effects on innate cells as shown by the inhibitory effects on IL-6 and nitric oxide production and confers protection in experimental autoimmune encephalomyelitis (EAE) model. However, these effects were not associated with an induction of HO-1 either in innate cells such as monocytes, dendritic cells and macrophages or in the kidneys and liver of IVIG-treated EAE mice. Also, inhibition of endogenous HO-1 did not modify anti-inflammatory effects of IVIG. These results thus indicate that IVIG exerts anti-inflammatory effects independent of HO-1 pathway.
publisher	Nature Publishing Group
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726216/
_version_	1613528150699933696

Heme oxygenase-1 is dispensable for the anti-inflammatory activity of intravenous immunoglobulin

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