Analysis of the N-terminal region of human MLKL, as well as two distinct MLKL isoforms, reveals new insights into necroptotic cell death

Analysis of the N-terminal region of human MLKL, as well as two distinct MLKL isoforms, reveals new insights into necroptotic cell death

We show that mixed lineage kinase domain-like (MLKL) isoform 2, which lacks the pseudokinase domain and activation loop phosphorylation sites, is a more potent activator of cell death compared with MLKL isoform 1. Both MLKL isoforms are expressed in human monocyte-derived macrophages.

Bibliographic Details
Main Authors: Arnež, Katja Hrovat, Kindlova, Michaela, Bokil, Nilesh J., Murphy, James M., Sweet, Matthew J., Gunčar, Gregor
Format: Online
Language:English
Published: Portland Press Ltd. 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725247/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725247/

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