Smac Mimetic-Induced Upregulation of CCL2/MCP-1 Triggers Migration and Invasion of Glioblastoma Cells and Influences the Tumor Microenvironment in a Paracrine Manner1
Second mitochondria-derived activator of caspase (Smac) mimetics are considered as promising anticancer therapeutics that are currently under investigation in early clinical trials. They induce apoptosis by antagonizing inhibitor of apoptosis proteins, which are frequently overexpressed in cancer. W...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Neoplasia Press
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719005/ |