Combined evaluation of hexokinase 2 and phosphorylated pyruvate dehydrogenase-E1α in invasive front lesions of colorectal tumors predicts cancer metabolism and patient prognosis

Combined evaluation of hexokinase 2 and phosphorylated pyruvate dehydrogenase-E1α in invasive front lesions of colorectal tumors predicts cancer metabolism and patient prognosis

Although numerous studies have shown the significance of cancer-specific aerobic glycolysis, how glycolysis contributes to tumor invasion, a critical phenomenon in metastasis, remains unclear. With regard to colorectal cancer (CRC), we studied two critical gate enzymes, hexokinase 2 (HK2), which is...

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Bibliographic Details
Main Authors: Hamabe, Atsushi, Yamamoto, Hirofumi, Konno, Masamitsu, Uemura, Mamoru, Nishimura, Junichi, Hata, Taishi, Takemasa, Ichiro, Mizushima, Tsunekazu, Nishida, Naohiro, Kawamoto, Koichi, Koseki, Jun, Doki, Yuichiro, Mori, Masaki, Ishii, Hideshi
Format: Online
Language:English
Published: BlackWell Publishing Ltd 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462394/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462394/

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