DNA Entry into and Exit out of the Cohesin Ring by an Interlocking Gate Mechanism

Structural maintenance of chromosome (SMC) complexes are proteinaceous rings that embrace DNA to enable vital chromosomal functions. The ring is formed by two SMC subunits, closed at a pair of ATPase heads, whose interaction is reinforced by a kleisin subunit. Using biochemical analysis of fission-y...

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Bibliographic Details
Main Authors: Murayama, Yasuto, Uhlmann, Frank
Format: Online
Language:English
Published: Cell Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701713/