Methylated arsenic metabolites bind to PML protein but do not induce cellular differentiation and PML-RARα protein degradation

Methylated arsenic metabolites bind to PML protein but do not induce cellular differentiation and PML-RARα protein degradation

Arsenic trioxide (As2O3) is one of the most effective therapeutic agents used for patients with acute promyelocytic leukemia (APL). The probable explanation for As2O3-induced cell differentiation is the direct targeting of PML-RARα oncoprotein by As2O3, which results in initiation of PML-RARa degrad...

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Bibliographic Details
Main Authors: Wang, Qian Qian, Zhou, Xin Yi, Zhang, Yan Fang, Bu, Na, Zhou, Jin, Cao, Feng Lin, Naranmandura, Hua
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694856/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694856/

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