A complex of Rab13 with MICAL-L2 and α-actinin-4 is essential for insulin-dependent GLUT4 exocytosis

A complex of Rab13 with MICAL-L2 and α-actinin-4 is essential for insulin-dependent GLUT4 exocytosis

Rab13 is necessary for insulin-regulated GLUT4-vesicle exocytosis in muscle. Biochemical and imaging analyses provide evidence that activated Rab13 engages a scaffold protein MICAL-L2 to form a complex with Rab13 and α-actinin-4. Through GLUT4 interaction with α-actinin-4, GLUT4 vesicles are recruit...

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Bibliographic Details
Main Authors: Sun, Yi, Jaldin-Fincati, Javier, Liu, Zhi, Bilan, Philip J., Klip, Amira
Format: Online
Language:English
Published: The American Society for Cell Biology 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694764/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694764/

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