Cerebrospinal Fluid Culture Positivity and Clinical Outcomes After Amphotericin-Based Induction Therapy for Cryptococcal Meningitis

Cerebrospinal Fluid Culture Positivity and Clinical Outcomes After Amphotericin-Based Induction Therapy for Cryptococcal Meningitis

Background. Amphotericin-based combination antifungal therapy reduces mortality from human immunodeficiency virus (HIV)-associated cryptococcal meningitis. However, 40%–50% of individuals have positive cerebrospinal fluid (CSF) fungal cultures at completion of 2 weeks of amphotericin induction thera...

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Main Authors: Rolfes, Melissa A., Rhein, Joshua, Schutz, Charlotte, Taseera, Kabanda, Nabeta, Henry W., Huppler Hullsiek, Kathy, Akampuira, Andrew, Rajasingham, Radha, Musubire, Abdu, Williams, Darlisha A., Thienemann, Friedrich, Bohjanen, Paul R., Muzoora, Conrad, Meintjes, Graeme, Meya, David B., Boulware, David R.
Format: Online
Language:English
Published: Oxford University Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692307/
id pubmed-4692307
recordtype oai_dc
spelling pubmed-46923072015-12-29 Cerebrospinal Fluid Culture Positivity and Clinical Outcomes After Amphotericin-Based Induction Therapy for Cryptococcal Meningitis Rolfes, Melissa A. Rhein, Joshua Schutz, Charlotte Taseera, Kabanda Nabeta, Henry W. Huppler Hullsiek, Kathy Akampuira, Andrew Rajasingham, Radha Musubire, Abdu Williams, Darlisha A. Thienemann, Friedrich Bohjanen, Paul R. Muzoora, Conrad Meintjes, Graeme Meya, David B. Boulware, David R. Major Articles Background. Amphotericin-based combination antifungal therapy reduces mortality from human immunodeficiency virus (HIV)-associated cryptococcal meningitis. However, 40%–50% of individuals have positive cerebrospinal fluid (CSF) fungal cultures at completion of 2 weeks of amphotericin induction therapy. Residual CSF culture positivity has historically been associated with poor clinical outcomes. We investigated whether persistent CSF fungemia was associated with detrimental clinical outcomes in a contemporary African cohort. Oxford University Press 2015-12-28 /pmc/articles/PMC4692307/ /pubmed/26716103 http://dx.doi.org/10.1093/ofid/ofv157 Text en © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Rolfes, Melissa A.
Rhein, Joshua
Schutz, Charlotte
Taseera, Kabanda
Nabeta, Henry W.
Huppler Hullsiek, Kathy
Akampuira, Andrew
Rajasingham, Radha
Musubire, Abdu
Williams, Darlisha A.
Thienemann, Friedrich
Bohjanen, Paul R.
Muzoora, Conrad
Meintjes, Graeme
Meya, David B.
Boulware, David R.
spellingShingle Rolfes, Melissa A.
Rhein, Joshua
Schutz, Charlotte
Taseera, Kabanda
Nabeta, Henry W.
Huppler Hullsiek, Kathy
Akampuira, Andrew
Rajasingham, Radha
Musubire, Abdu
Williams, Darlisha A.
Thienemann, Friedrich
Bohjanen, Paul R.
Muzoora, Conrad
Meintjes, Graeme
Meya, David B.
Boulware, David R.
Cerebrospinal Fluid Culture Positivity and Clinical Outcomes After Amphotericin-Based Induction Therapy for Cryptococcal Meningitis
author_facet Rolfes, Melissa A.
Rhein, Joshua
Schutz, Charlotte
Taseera, Kabanda
Nabeta, Henry W.
Huppler Hullsiek, Kathy
Akampuira, Andrew
Rajasingham, Radha
Musubire, Abdu
Williams, Darlisha A.
Thienemann, Friedrich
Bohjanen, Paul R.
Muzoora, Conrad
Meintjes, Graeme
Meya, David B.
Boulware, David R.
author_sort Rolfes, Melissa A.
title Cerebrospinal Fluid Culture Positivity and Clinical Outcomes After Amphotericin-Based Induction Therapy for Cryptococcal Meningitis
title_short Cerebrospinal Fluid Culture Positivity and Clinical Outcomes After Amphotericin-Based Induction Therapy for Cryptococcal Meningitis
title_full Cerebrospinal Fluid Culture Positivity and Clinical Outcomes After Amphotericin-Based Induction Therapy for Cryptococcal Meningitis
title_fullStr Cerebrospinal Fluid Culture Positivity and Clinical Outcomes After Amphotericin-Based Induction Therapy for Cryptococcal Meningitis
title_full_unstemmed Cerebrospinal Fluid Culture Positivity and Clinical Outcomes After Amphotericin-Based Induction Therapy for Cryptococcal Meningitis
title_sort cerebrospinal fluid culture positivity and clinical outcomes after amphotericin-based induction therapy for cryptococcal meningitis
description Background. Amphotericin-based combination antifungal therapy reduces mortality from human immunodeficiency virus (HIV)-associated cryptococcal meningitis. However, 40%–50% of individuals have positive cerebrospinal fluid (CSF) fungal cultures at completion of 2 weeks of amphotericin induction therapy. Residual CSF culture positivity has historically been associated with poor clinical outcomes. We investigated whether persistent CSF fungemia was associated with detrimental clinical outcomes in a contemporary African cohort.
publisher Oxford University Press
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692307/
_version_ 1613517088454868992

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